Matrix metalloproteases and their tissue inhibitor in cardiac transplantation☆☆☆
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteases and their tissue inhibitor in cardiac transplantation.
OBJECTIVE Multiple studies have shown that matrix metalloproteases (MMPs) are involved in the pathologic reactions occurring as a consequence of cardiac transplantation, including ischemia-reperfusion injury and allograft rejection. This study sought to determine the temporal profile of MMP serum levels following cardiac transplantation. METHODS Endomyocardial biopsies and serum samples were ...
متن کاملChanging Roles of Matrix Metalloproteases and Their Inhibitors, TIMPs, During Tumor Progression and Angiogenesis
Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...
متن کاملThe inhibition of matrix metalloproteases by tissue inhibitors of metalloproteases revealed by X-ray crystallography.
B , Rezmkoff, W , Riley, M , Schaechter, M and Umbarger, H E eds ) 419-428, American Society for Microbiology, Washington DC Lewis M , et al and Lu P (1996) Crystal structure of the lactose operon repressor and its complexes with DNA and mducei Science 271 , 1247-1254 Schell M A (1993) Molecular biology of the LysR family of transcriptional regulators Annu Re\ Microbiol 47, 597-626 Schumacher M...
متن کاملMatrix metalloproteases and lung disease.
healing are just some of the physiological processes in which the matrix metalloproteases (MMPs), a family of highly homologous endo-peptidases, play a crucial part.'" Collectively the MMPs can cleave most, if not all, the protein constituents of the extracellular matrix including collagen, proteoglycan, laminin, fibronectin, and elastin. In so doing they facilitate cell movement, reorientation...
متن کاملMatrix metalloproteases and PAR1 activation.
Cardiovascular diseases, including atherothrombosis, are the leading cause of morbidity and mortality in the United States, Europe, and the developed world. Matrix metalloproteases (MMPs) have recently emerged as important mediators of platelet and endothelial function, and atherothrombotic disease. Protease-activated receptor-1 (PAR1) is a G protein-coupled receptor that is classically activat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2007
ISSN: 1010-7940
DOI: 10.1016/j.ejcts.2007.04.007